Gene
cdc14ab
- ID
- ZDB-GENE-070705-309
- Name
- cell division cycle 14Ab
- Symbol
- cdc14ab Nomenclature History
- Previous Names
-
- cdc14a2 (1)
- si:dkey-168j9.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in cilium assembly; microtubule cytoskeleton organization; and regulation of cell cycle process. Predicted to act upstream of or within cell division and protein dephosphorylation. Predicted to be located in several cellular components, including cell projection; cytoskeleton; and nucleus. Predicted to be active in microtubule cytoskeleton and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 32 | Alliance | Deafness, autosomal recessive 32, with or without immotile sperm | 608653 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Domain | IPR029260 | Dual specificity/tyrosine protein phosphatase, N-terminal |
| Domain | IPR044506 | Dual-specificity phosphatase CDC14, C-terminal |
| Family | IPR050561 | Protein Tyrosine Phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Length | Dual specificity phosphatase, catalytic domain | Dual-specificity phosphatase CDC14, C-terminal | Dual specificity protein phosphatase domain | Dual specificity/tyrosine protein phosphatase, N-terminal | Protein Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PDX1
|
595 | ||||||||
|
UniProtKB:A5PMX2
|
510 | ||||||||
|
UniProtKB:A0A0R4IVA4
|
611 | ||||||||
|
UniProtKB:A0A8M9PJL3
|
537 | ||||||||
|
UniProtKB:A0A8M2B8K4
|
509 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdc14ab-201
(1)
|
Ensembl | 4,436 nt | ||
| mRNA |
cdc14ab-202
(1)
|
Ensembl | 510 nt | ||
| mRNA |
cdc14ab-203
(1)
|
Ensembl | 5,359 nt |
Interactions and Pathways
No data available
Plasmids
No data available