ZFIN ID: ZDB-GENE-070705-262
Gene Name: kringle containing transmembrane protein 1
Gene Symbol: kremen1    Nomenclature History

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Previous Names: krm1 (1), si:ct737139.1, si:dkeyp-7c9.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and transferase activity. Involved in angiogenesis; lateral line development; and liver development. Predicted to localize to the integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia. Is expressed in lens; midbrain hindbrain boundary; otic vesicle; posterior lateral line primordium; and ventral fin fold. Orthologous to several human genes including KREMEN1 (kringle containing transmembrane protein 1).
Genome Resources: Alliance (1),  Gene:100141352 (1),  Ensembl(GRCz11):ENSDARG00000062579 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
nl10 Point Mutation Donor Splice Site of Intron 6 Splice Site, Frameshift, Premature Stop ENU
sa1168 Point Mutation Unknown Premature Stop ENU
sa33555 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kremen1 N/A 4
    MO2-kremen1 N/A 2
    MO3-kremen1 N/A 2
    MO4-kremen1 N/A 1
    DISEASE ASSOCIATED WITH kremen1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Ectodermal dysplasia 13, hair/tooth type 617392
    DISEASE ASSOCIATED WITH kremen1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000001 Kringle
    Domain IPR000859 CUB domain
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR002889 Carbohydrate-binding WSC
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Homologous_superfamily IPR013806 Kringle-like fold
    Conserved_site IPR018056 Kringle, conserved site
    Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
    Homologous_superfamily IPR038178 Kringle superfamily
    Domain IPR040700 ZNRF-3, ectodomain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kremen1-203 (1)    Ensembl 867
    ncRNA kremen1-002 (1)    Ensembl 673
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kremen1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:kremen1-GFP) hsp70l GFPkremen1 Danio rerio 1 2
    MARKER RELATIONSHIPS
    kremen1 Contained in: [BAC] DKEYP-7C9 (1)
    kremen1 Encodes: [cDNA] MGC:171555 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114917 (1) 2392 bp
    Genomic GenBank:CT737139 (1) 159336 bp
    Select Tool
    Polypeptide UniProtKB:A5WWA0 (1) 868 aa
    Sequence Information (all 18)
    ORTHOLOGY for kremen1 ( Chr: 5 )
    CITATIONS (23)