Gene

kremen1

ID
ZDB-GENE-070705-262
Name
kringle containing transmembrane protein 1
Symbol
kremen1 Nomenclature History
Previous Names
  • krm1 (1)
  • si:ct737139.1
  • si:dkeyp-7c9.1 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity and transferase activity. Involved in angiogenesis; lateral line development; and liver development. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in lens; midbrain hindbrain boundary; otic vesicle; posterior lateral line primordium; and ventral fin fold. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to several human genes including KREMEN1 (kringle containing transmembrane protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kremen1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ectodermal dysplasia 13 Alliance Ectodermal dysplasia 13, hair/tooth type 617392
Associated With kremen1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018056 Kringle, conserved site
Domain IPR000001 Kringle
Domain IPR000859 CUB domain
Domain IPR001841 Zinc finger, RING-type
Domain IPR002889 Carbohydrate-binding WSC
Domain IPR040700 ZNRF-3, ectodomain
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Homologous_superfamily IPR038178 Kringle superfamily
Domain Details Per Protein
Protein Length Carbohydrate-binding WSC CUB domain Kringle Kringle, conserved site Kringle-like fold Kringle superfamily Spermadhesin, CUB domain superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type ZNRF-3, ectodomain
UniProtKB:F1QB55 289
UniProtKB:A5WWA0 868
UniProtKB:B0BLV6 465
UniProtKB:M5AN93 465
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations