Gene
malt1
- ID
- ZDB-GENE-070705-156
- Name
- MALT paracaspase 1
- Symbol
- malt1 Nomenclature History
- Previous Names
-
- malt1b
- paracaspase
- pcasp1b
- si:ch211-261c8.3
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and proteolysis. Human ortholog(s) of this gene implicated in lymphoma; non-Hodgkin lymphoma; and primary immunodeficiency disease. Orthologous to human MALT1 (MALT1 paracaspase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 12 | Alliance | Immunodeficiency 12 | 615468 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR011600 | Peptidase C14, caspase domain |
| Domain | IPR037940 | MALT1, death domain |
| Domain | IPR041077 | MALT1 immunoglobulin-like domain |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
| Homologous_superfamily | IPR033540 | MALT1, immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Caspase-like domain superfamily | Death-like domain superfamily | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin subtype 2 | MALT1, death domain | MALT1 immunoglobulin-like domain | MALT1, immunoglobulin-like domain superfamily | Peptidase C14, caspase domain | Peptidase C14, p20 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TDU1
|
792 | ||||||||||||
|
UniProtKB:A0A8M2BCW4
|
817 |
Interactions and Pathways
No data available
Plasmids
No data available