ZFIN is now using GRCz12tu for Genomic Data
Gene
ripk1l
- ID
- ZDB-GENE-070705-132
- Name
- receptor (TNFRSF)-interacting serine-threonine kinase 1, like
- Symbol
- ripk1l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable JUN kinase kinase kinase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including head; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 57 | Alliance | Immunodeficiency 57 with autoinflammation | 618108 |
| Autoinflammation with episodic fever and lymphadenopathy | 618852 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR025735 | RIP homotypic interaction motif |
| Domain | IPR000488 | Death domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR037934 | RIP1, Death domain |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | RIP1, Death domain | RIP homotypic interaction motif | Serine/Threonine Kinases and Pseudokinases | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q0MSH9 | InterPro | 661 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ripk1l-201
(1)
|
Ensembl | 2,194 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers