Gene

ripk1l

ID

ZDB-GENE-070705-132

Name

receptor (TNFRSF)-interacting serine-threonine kinase 1, like

Symbol

ripk1l Nomenclature History

Previous Names

RIP1 (1)
Ripk1 (1)
si:ch211-241e1.1

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have JUN kinase kinase kinase activity. Predicted to be involved in activation of JUN kinase activity. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ripk1l Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 57	Alliance	Immunodeficiency 57 with autoinflammation	618108
		Autoinflammation with episodic fever and lymphadenopathy	618852

Associated With ripk1l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000488	Death domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR025735	RHIM domain
Domain	IPR037934	RIP1, Death domain
Family	IPR050167	Serine/threonine-protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011029	Death-like domain superfamily