Gene

ripk1l

ID
ZDB-GENE-070705-132
Name
receptor (TNFRSF)-interacting serine-threonine kinase 1, like
Symbol
ripk1l Nomenclature History
Previous Names
  • RIP1 (1)
  • Ripk1 (1)
  • si:ch211-241e1.1
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have JUN kinase kinase kinase activity. Predicted to be involved in activation of JUN kinase activity. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ripk1l Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 57 Alliance Immunodeficiency 57 with autoinflammation 618108
Autoinflammation with episodic fever and lymphadenopathy 618852
Associated With ripk1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000488 Death domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR025735 RHIM domain
Domain IPR037934 RIP1, Death domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily Protein kinase domain Protein kinase-like domain superfamily RHIM domain RIP1, Death domain Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:B3DK89 675
UniProtKB:Q0MSH9 661
UniProtKB:A8DZG7 661
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations