Gene
rragd
- ID
- ZDB-GENE-070620-6
- Name
- ras-related GTP binding D
- Symbol
- rragd Nomenclature History
- Previous Names
-
- zgc:162165
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular response to starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm and membrane. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Human ortholog(s) of this gene implicated in renal hypomagnesemia 7, with or without dilated cardiomyopathy. Orthologous to human RRAGD (Ras related GTP binding D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ding et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| st166 | Allele with one delins | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rragd | Bouchard et al., 2023 | |
| MO1-rragd | N/A | Adella et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| renal hypomagnesemia 7, with or without dilated cardiomyopathy | Alliance | Hypomagnesemia 7, renal, with or without dilated cardiomyopathy | 620152 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Gtr1/RagA G protein | P-loop containing nucleoside triphosphate hydrolase | RagC/D |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PNV5 | InterPro | 252 | |||
| UniProtKB:F1QIB5 | InterPro | 394 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-315M17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162165 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099424 (1) | 2666 nt | ||
| Genomic | GenBank:CU467635 (2) | 80145 nt | ||
| Polypeptide | UniProtKB:F1QIB5 (1) | 394 aa |
- Adella, A., Tengku, F., Arjona, F.J., Broekman, S., de Vrieze, E., van Wijk, E., Hoenderop, J.G.J., de Baaij, J.H.F. (2024) RRAGD variants cause cardiac dysfunction in a zebrafish model. American journal of physiology. Heart and circulatory physiology. 327(5):H1187-H1197
- Bouchard, E.L., Meireles, A.M., Talbot, W.S. (2023) Oligodendrocyte development and myelin sheath formation are regulated by the antagonistic interaction between the Rag-Ragulator complex and TFEB. Glia. 72(2):289-299
- Feng, N., Bian, Z., Zhang, X., Wang, C., Chen, J. (2018) Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Singapore medical journal. 60(5):241-246
- Li, Y.C., Zhang, M.Q., Zhang, J.P. (2018) Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish. Frontiers in cellular and infection microbiology. 8:109
- Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xue, Y., Gao, S., Liu, F. (2015) Genome-wide Analysis of the Zebrafish Klf Family Identifies Two Genes important for Erythroid Maturation. Developmental Biology. 403(2):115-27
- Zhao, Y., Qin, W., Zhang, J.P., Hu, Z.Y., Tong, J.W., Ding, C.B., Peng, Z.G., Zhao, L.X., Song, D.Q., and Jiang, J.D. (2013) HCV IRES-Mediated Core Expression in Zebrafish. PLoS One. 8(3):e56985
- Ding, C.B., Zhang, J.P., Zhao, Y., Peng, Z.G., Song, D.Q., and Jiang, J.D. (2011) Zebrafish as a potential model organism for drug test against hepatitis C virus. PLoS One. 6(8):e22921
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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