Gene
kcnk1a
- ID
- ZDB-GENE-070620-26
- Name
- potassium channel, subfamily K, member 1a
- Symbol
- kcnk1a Nomenclature History
- Previous Names
-
- kcnk1
- im:7150627
- zgc:165664 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables outward rectifier potassium channel activity. Acts upstream of or within heart process. Predicted to be located in several cellular components, including apical plasma membrane; perikaryon; and recycling endosome. Predicted to be active in plasma membrane. Is expressed in brain and heart. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150627 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Christensen et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-kcnk1a | N/A | Christensen et al., 2016 |
| MO2-kcnk1a | N/A | Christensen et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013099 | Potassium channel domain |
| Family | IPR001779 | Two pore domain potassium channel, TWIK-1 |
| Family | IPR003092 | Two pore domain potassium channel, TASK family |
| Family | IPR003280 | Two pore domain potassium channel |
| Family | IPR005408 | Two pore domain potassium channel, TWIK family |
Domain Details Per Protein
| Protein | Additional Resources | Length | Potassium channel domain | Two pore domain potassium channel | Two pore domain potassium channel, TASK family | Two pore domain potassium channel, TWIK-1 | Two pore domain potassium channel, TWIK family |
|---|---|---|---|---|---|---|---|
| UniProtKB:A5PLK0 | InterPro | 338 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnk1a-201
(1)
|
Ensembl | 1,469 nt | ||
| mRNA |
kcnk1a-202
(1)
|
Ensembl | 812 nt | ||
| mRNA |
kcnk1a-203
(1)
|
Ensembl | 1,531 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-28P3 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7150627 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:165664 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098753 (1) | 1482 nt | ||
| Genomic | GenBank:CR381684 (1) | 184232 nt | ||
| Polypeptide | UniProtKB:A5PLK0 (1) | 338 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Qiu, W., Liu, S., Yang, F., Dong, P., Yang, M., Wong, M., Zheng, C. (2019) Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Ecotoxicology and environmental safety. 174:181-188
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Christensen, A.H., Chatelain, F.C., Huttner, I.G., Olesen, M.S., Soka, M., Feliciangeli, S., Horvat, C., Santiago, C.F., Vandenberg, J.I., Schmitt, N., Olesen, S.P., Lesage, F., Fatkin, D. (2016) The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. Journal of Molecular and Cellular Cardiology. 97:24-35
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gierten, J., Hassel, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2012) Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biomembranes. 1818(1):33-41
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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