ZFIN is now using GRCz12tu for Genomic Data
Gene
nadsyn1
- ID
- ZDB-GENE-070615-22
- Name
- NAD synthetase 1
- Symbol
- nadsyn1 Nomenclature History
- Previous Names
-
- zgc:165489
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable NAD+ synthase (glutamine-hydrolyzing) activity and glutaminase activity. Predicted to be involved in NAD+ biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Vertebral, cardiac, renal, and limb defects syndrome 3 | 618845 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003010 | Carbon-nitrogen hydrolase |
| Domain | IPR022310 | NAD/GMP synthase |
| Family | IPR003694 | NAD(+) synthetase |
| Family | IPR014445 | Glutamine-dependent NAD(+) synthetase |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036526 | Carbon-nitrogen hydrolase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Carbon-nitrogen hydrolase | Carbon-nitrogen hydrolase superfamily | Glutamine-dependent NAD(+) synthetase | NAD/GMP synthase | NAD(+) synthetase | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A5PLA8 | InterPro | 694 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nadsyn1-201
(1)
|
Ensembl | 567 nt | ||
| mRNA |
nadsyn1-202
(1)
|
Ensembl | 1,773 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers