Gene

casp10

ID

ZDB-GENE-070608-2

Name

caspase 10, apoptosis-related cysteine peptidase

Symbol

casp10 Nomenclature History

Previous Names

casp8l2
caspase-8b (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway and death effector domain binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Predicted to be active in cytoplasm. Is expressed in floor plate; intestinal bulb; muscle cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2A; non-Hodgkin lymphoma; and stomach cancer. Orthologous to human CASP10 (caspase 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With casp10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 2A	Alliance	Autoimmune lymphoproliferative syndrome, type II	603909
non-Hodgkin lymphoma	Alliance	Lymphoma, non-Hodgkin, somatic	605027
stomach cancer	Alliance	Gastric cancer, somatic	613659

Associated With casp10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016129	Peptidase family C14A, His active site
Active_site	IPR033139	Peptidase family C14A, cysteine active site
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR001875	Death effector domain
Domain	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
Domain	IPR011600	Peptidase C14, caspase domain
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR029030	Caspase-like domain superfamily

Domain Details Per Protein

Protein	Length	Caspase-like domain superfamily	Death effector domain	Death-like domain superfamily	Peptidase C14A, caspase catalytic domain	Peptidase C14, caspase domain	Peptidase C14, caspase non-catalytic subunit p10	Peptidase C14, p20 domain	Peptidase family C14A, cysteine active site	Peptidase family C14A, His active site
UniProtKB:E7EXV8 InterPro	520

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	casp8l2-202 (1) Ensembl	Ensembl	763 nt	Select Tool ZFIN BLAST
mRNA	casp8l2-203 (1) Ensembl	Ensembl	747 nt	Select Tool ZFIN BLAST
mRNA	casp10-201 (1) Ensembl	Ensembl	2,061 nt	Select Tool ZFIN BLAST
mRNA	casp10-204 (1) Ensembl	Ensembl	2,145 nt	Select Tool ZFIN BLAST
mRNA	casp10-205 (1) Ensembl	Ensembl	1,672 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations