Gene

casp3b

ID
ZDB-GENE-070607-1
Name
caspase 3, apoptosis-related cysteine peptidase b
Symbol
casp3b Nomenclature History
Previous Names
  • casp3l
  • caspase-3b (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be involved in several processes, including erythrocyte differentiation; keratinocyte differentiation; and positive regulation of apoptotic process. Predicted to act upstream of or within proteolysis. Predicted to be active in cytoplasm. Is expressed in intestinal bulb; muscle cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP3 (caspase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With casp3b Human Ortholog
No data available
Associated With casp3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR033139 Peptidase family C14A, cysteine active site
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR002138 Peptidase C14, caspase non-catalytic subunit p10
Domain IPR015917 Peptidase C14A, caspase catalytic domain
Family IPR002398 Peptidase C14 family
Family IPR015471 Caspase-3/7
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Domain Details Per Protein
Protein Length Caspase-3/7 Caspase-like domain superfamily Peptidase C14A, caspase catalytic domain Peptidase C14, caspase non-catalytic subunit p10 Peptidase C14 family Peptidase C14, p20 domain Peptidase family C14A, cysteine active site
UniProtKB:Q0PKX2 285
UniProtKB:F1Q7K7 285
UniProtKB:A0A2U9DQJ9 285
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations