Gene

arhgef11

ID
ZDB-GENE-070604-1
Name
Rho guanine nucleotide exchange factor (GEF) 11
Symbol
arhgef11 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including epithelial cilium movement involved in extracellular fluid movement; otolith development; and stress fiber assembly. Predicted to localize to cytoplasm. Is expressed in central nervous system; head; and pronephric duct. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Panizzi et al., 2007
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Panizzi et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With arhgef11 Human Ortholog
No data available
Associated With arhgef11 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR001478 PDZ domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR015212 Regulator of G protein signalling-like domain
Domain IPR037889 Rho guanine nucleotide exchange factor 11, RGS domain
Domain IPR041020 ARHGEF1-like, PH domain
Family IPR032919 Rho guanine nucleotide exchange factor 11
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036305 RGS domain superfamily
Domain Details Per Protein
Protein Length ARHGEF1-like, PH domain Dbl homology (DH) domain Dbl homology (DH) domain superfamily Guanine-nucleotide dissociation stimulator, CDC24, conserved site PDZ domain PDZ superfamily PH-like domain superfamily Pleckstrin homology domain Regulator of G protein signalling-like domain RGS domain superfamily Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 11, RGS domain
UniProtKB:Q49U75 1417
UniProtKB:B0S635 555
UniProtKB:B3DJQ2 1417
UniProtKB:A0A140LFR2 174
UniProtKB:A0A140LG62 852
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations