Gene
xpo1b
- ID
- ZDB-GENE-070530-6
- Name
- exportin 1 (CRM1 homolog, yeast) b
- Symbol
- xpo1b Nomenclature History
- Previous Names
-
- xpo1
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable nuclear export signal receptor activity. Acts upstream of or within response to yeast. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-xpo1b | LaCoursiere et al., 2024 | |
| CRISPR2-xpo1b | LaCoursiere et al., 2024 | |
| CRISPR3-xpo1b | LaCoursiere et al., 2024 | |
| CRISPR4-xpo1b | LaCoursiere et al., 2024 | |
| MO1-xpo1b | N/A | Bagheri et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001494 | Importin-beta, N-terminal domain |
| Domain | IPR013598 | Exportin-1/Importin-beta-like |
| Domain | IPR014877 | Exportin-1, C-terminal |
| Family | IPR045065 | Exportin-1/5 |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Repeat | IPR040485 | Exportin-1, repeat 3 |
| Repeat | IPR041123 | Chromosome region maintenance repeat |
| Repeat | IPR041235 | Exportin-1, repeat 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Chromosome region maintenance repeat | Exportin-1/5 | Exportin-1, C-terminal | Exportin-1/Importin-beta-like | Exportin-1, repeat 2 | Exportin-1, repeat 3 | Importin-beta, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PPG9 | InterPro | 1071 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-63B16 | ||
| Contained in | BAC | CH211-189K9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009293053 (1) | 4941 nt | ||
| Genomic | GenBank:BX469915 (1) | 172252 nt | ||
| Polypeptide | UniProtKB:A0A8M9PPG9 (1) | 1071 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Bagheri, H., Badduke, C., Qiao, Y., Colnaghi, R., Abramowicz, I., Alcantara, D., Dunham, C., Wen, J., Wildin, R.S., Nowaczyk, M.J., Eichmeyer, J., Lehman, A., Maranda, B., Martell, S., Shan, X., Lewis, S.M., O'Driscoll, M., Gregory-Evans, C.Y., Rajcan-Separovic, E. (2016) Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis. JCI insight. 1:e85461
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y.C., Lin, C., Chuang, M.T., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., and Chen, B.S. (2013) Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC systems biology. 7:79
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