Gene

zfhx4

ID

ZDB-GENE-070530-3

Name

zinc finger homeobox 4

Symbol

zfhx4 Nomenclature History

Previous Names

im:7159242 (1)
si:ch211-94d7.1

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in brain; midbrain neural keel; pharyngeal arch; and retinal ganglion cell layer. Orthologous to human ZFHX4 (zinc finger homeobox 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159242 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zfhx4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital ptosis	Alliance	?Ptosis, congenital	178300

Associated With zfhx4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR051968	Zinc finger homeobox transcription regulators
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeobox, conserved site	Homeodomain	Matrin/U1-C-like, C2H2-type zinc finger	Zinc finger C2H2 superfamily	Zinc finger C2H2-type	Zinc finger homeobox transcription regulators
UniProtKB:E7FCF7 InterPro	3489
UniProtKB:A0A8M9PR14 InterPro	2447
UniProtKB:F6NXU9 InterPro	3528

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zfhx4-201 (1) Ensembl	Ensembl	14,414 nt	Select Tool ZFIN BLAST
mRNA	zfhx4-202 (1) Ensembl	Ensembl	13,851 nt	Select Tool
mRNA	zfhx4-203 (1) Ensembl	Ensembl	14,531 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations