Gene

pex2

ID
ZDB-GENE-070530-2
Name
peroxisomal biogenesis factor 2
Symbol
pex2 Nomenclature History
Previous Names
  • pxmp3
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable ubiquitin protein ligase activity. Involved in peroxisome organization. Predicted to be located in peroxisomal membrane. Used to study Zellweger syndrome. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 5B and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Takashima et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
gf1Allele with one deletionExon 2Frameshift, Premature StopTALEN
gf2Allele with one deletionExon 2Frameshift, Premature StopTALEN
1 - 2 of 2
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
TALEN1-pex2Takashima et al., 2021
1 - 1 of 1
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Human Disease
Associated With pex2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
peroxisome biogenesis disorder 5A Alliance Peroxisome biogenesis disorder 5A (Zellweger) 614866
Peroxisome biogenesis disorder 5B Alliance Peroxisome biogenesis disorder 5B 614867
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Associated With pex2 Via Experimental Models
Human Disease Fish Conditions Citations
Zellweger syndrome pex2gf2/gf2 (RW) standard conditions Takashima et al., 2021
Zellweger syndrome pex2gf1/gf1 (RW) standard conditions Takashima et al., 2021
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein Additional Resources Length
UniProtKB:A0A9B7QDH4 InterPro 312
UniProtKB:A0AB13AB84 InterPro 312
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 24
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pex2-201 (1)
Ensembl
Ensembl 1,297 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-122G18
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001423777 (1)2686 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CR361560 (1)184660 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A9B7QDH4 (1)312 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPEX28
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MousePex23
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
TSV
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