Gene

pex2

ID

ZDB-GENE-070530-2

Name

peroxisomal biogenesis factor 2

Symbol

pex2 Nomenclature History

Previous Names

pxmp3

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Takashima et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pex2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
peroxisome biogenesis disorder 5A	Alliance	Peroxisome biogenesis disorder 5A (Zellweger)	614866
Peroxisome biogenesis disorder 5B	Alliance	Peroxisome biogenesis disorder 5B	614867

Associated With pex2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Zellweger syndrome	pex2^gf2/gf2 (RW)	standard conditions	Takashima et al., 2021
Zellweger syndrome	pex2^gf1/gf1 (RW)	standard conditions	Takashima et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR006845	Pex, N-terminal
Domain	IPR018957	Zinc finger, C3HC4 RING-type
Domain	IPR045859	Peroxisome biogenesis factor 2, HC subclass-RING finger domain
Family	IPR025654	Peroxisome biogenesis factor 2/10
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type