Gene
cers6
- ID
- ZDB-GENE-070522-1
- Name
- ceramide synthase 6
- Symbol
- cers6 Nomenclature History
- Previous Names
-
- lass6
- si:ch211-278b7.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane and nucleus. Is expressed in several structures, including central nervous system; intestine; pronephros; spinal cord neural tube; and trigeminal placode. Orthologous to human CERS6 (ceramide synthase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Brondolin et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027055Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15899 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeodomain | Sphingosine N-acyltransferase Lag1/Lac1-like | TRAM/LAG1/CLN8 homology domain |
|---|---|---|---|---|---|---|
| UniProtKB:F1QPF3 | InterPro | 391 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-278B7 | ||
| Contained in | Fosmid | CH1073-146B10 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-374J5 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-462F18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_688191 (1) | 2088 nt | ||
| Genomic | GenBank:CR626882 (1) | 162232 nt | ||
| Polypeptide | UniProtKB:F1QPF3 (1) | 391 aa |
- Armistead, J., Höpfl, S., Goldhausen, P., Müller-Hartmann, A., Fahle, E., Hatzold, J., Franzen, R., Brodesser, S., Radde, N.E., Hammerschmidt, M. (2024) A sphingolipid rheostat controls apoptosis versus apical cell extrusion as alternative tumour-suppressive mechanisms. Cell Death & Disease. 15:746746
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Zhang, A.N., Huang, C., Yan, L., Liu, X., Wang, F., Zhang, Z., Li, L., Zhang, C., Zhang, Q. (2023) Metabolic regulation and antihyperglycemic properties of diet-derived PGG through transcriptomic and metabolomic profiling. Food & function. 14(12):5620-5630
- Sun, S., Cao, X., Gao, J. (2021) C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage. iScience. 24:103409
- Zhang, T., Trauger, S.A., Vidoudez, C., Doane, K.P., Pluimer, B.R., Peterson, R.T. (2019) Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Scientific Reports. 9:19939
- Mendelson, K., Pandey, S., Hisano, Y., Carellini, F., Das, B., Hla, T., Evans, T. (2017) The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine Levels during zebrafish embryogenesis. eLIFE. 6
- Brondolin, M., Berger, S., Reinke, M., Tanaka, H., Ohshima, T., Fuss, B., and Hoch, M. (2013) Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(2):189-200
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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