Gene
drd4b
- ID
- ZDB-GENE-070508-3
- Name
- dopamine receptor D4b
- Symbol
- drd4b Nomenclature History
- Previous Names
-
- drd4c (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within adenylate cyclase-inhibiting dopamine receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in endoderm; nervous system; neural tube; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| attention deficit hyperactivity disorder | Alliance | {Attention deficit-hyperactivity disorder} | 143465 |
| Autonomic nervous system dysfunction |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dopamine D4 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:Q5DJ14
|
382 |
Interactions and Pathways
No data available
Plasmids