Gene
drd4b
- ID
- ZDB-GENE-070508-3
- Name
- dopamine receptor D4b
- Symbol
- drd4b Nomenclature History
- Previous Names
-
- drd4c (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to localize to dendrite and integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Is expressed in endoderm; nervous system; neural tube; and pharyngeal arch 3-7 skeleton. Orthologous to human DRD4 (dopamine receptor D4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| attention deficit hyperactivity disorder | Alliance | {Attention deficit-hyperactivity disorder} | 143465 |
| Autonomic nervous system dysfunction |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dopamine D4 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:Q5DJ14
|
382 |
Interactions and Pathways
No data available
Plasmids