ZFIN is now using GRCz12tu for Genomic Data
Gene
grin2ab
- ID
- ZDB-GENE-070424-223
- Name
- glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
- Symbol
- grin2ab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable NMDA glutamate receptor activity. Acts upstream of or within swimming behavior and thigmotaxis. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137621 (4 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Landau-Kleffner syndrome | Alliance | Epilepsy, focal, with speech disorder and with or without impaired intellectual development | 245570 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR018884 | Glutamate [NMDA] receptor, epsilon subunit, C-terminal |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutamate [NMDA] receptor, epsilon subunit, C-terminal | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PIL3 | InterPro | 1393 | |||||||
| UniProtKB:F1QDE5 | InterPro | 1445 | |||||||
| UniProtKB:A0A8M9PIL7 | InterPro | 147 | |||||||
| UniProtKB:A0AC58JG37 | InterPro | 1445 | |||||||
| UniProtKB:A0AC58JG38 | InterPro | 1445 | |||||||
| UniProtKB:A0AC58JG40 | InterPro | 1325 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grin2ab-201
(1)
|
Ensembl | 7,364 nt | ||
| mRNA |
grin2ab-202
(1)
|
Ensembl | 5,416 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers