Gene

kitlgb

ID
ZDB-GENE-070424-2
Name
kit ligand b
Symbol
kitlgb Nomenclature History
Previous Names
  • kitlb (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within embryonic hemopoiesis and hematopoietic stem cell homeostasis. Predicted to be located in several cellular components, including extracellular region; filopodium; and lamellipodium. Predicted to be active in plasma membrane. Is expressed in several structures, including caudal vein plexus; central nervous system; gonad; kidney; and otic vesicle. Human ortholog(s) of this gene implicated in Waardenburg's syndrome; autosomal dominant nonsyndromic deafness 69; and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Mahony et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kitlgb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 69 Alliance Deafness, autosomal dominant 69, unilateral or asymmetric 616697
familial progressive hyperpigmentation with or without hypopigmentation Alliance Hyperpigmentation with or without hypopigmentation 145250
Waardenburg syndrome, type 2F 619947
[Skin/hair/eye pigmentation 7, blond/brown hair] 611664
Associated With kitlgb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR003452 Stem cell factor
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
Domain Details Per Protein
Protein Length Four-helical cytokine-like, core Stem cell factor
UniProtKB:Q56JH5 267
UniProtKB:F1RDP0 267
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations