Gene

farp1

ID

ZDB-GENE-070424-163

Name

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

Symbol

farp1 Nomenclature History

Previous Names

si:ch211-235f1.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have Rac guanyl-nucleotide exchange factor activity; phosphatidylinositol phosphate binding activity; and phosphatidylserine binding activity. Involved in glomerular filtration. Predicted to localize to cytoskeleton. Orthologous to human FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Rinschen et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With farp1 Human Ortholog

No data available

Associated With farp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000299	FERM domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR014847	FERM adjacent
Domain	IPR018979	FERM, N-terminal
Domain	IPR018980	FERM, C-terminal PH-like domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR041788	FARP1/FARP2/FRMD7, FERM domain C-lobe
Family	IPR000798	Ezrin/radixin/moesin-like
Family	IPR051835	RAC1-specific guanine nucleotide exchange factor
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Length	Band 4.1 domain	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Ezrin/radixin/moesin-like	FARP1/FARP2/FRMD7, FERM domain C-lobe	FERM/acyl-CoA-binding protein superfamily	FERM adjacent	FERM central domain	FERM conserved site	FERM, C-terminal PH-like domain	FERM domain	FERM, N-terminal	FERM superfamily, second domain	PH-like domain superfamily	Pleckstrin homology domain	RAC1-specific guanine nucleotide exchange factor	Ubiquitin-like domain superfamily
UniProtKB:A0A8M6Z6P5 InterPro	1041

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	farp1-201 (1) Ensembl	Ensembl	824 nt	Select Tool
mRNA	farp1-203 (1) Ensembl	Ensembl	3,696 nt	Select Tool
mRNA	farp1-204 (1) Ensembl	Ensembl	2,616 nt	Select Tool
mRNA	farp1-206 (1) Ensembl	Ensembl	426 nt	Select Tool ZFIN BLAST
mRNA	farp1-207 (1) Ensembl	Ensembl	789 nt	Select Tool ZFIN BLAST
ncRNA	farp1-003 (1) Ensembl	Ensembl	560 nt	Select Tool
ncRNA	farp1-005 (1) Ensembl	Ensembl	638 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations