Gene
nlrp3
- ID
- ZDB-GENE-070424-110
- Name
- NLR family pyrin domain containing 3
- Symbol
- nlrp3 Nomenclature History
- Previous Names
-
- si:ch211-114l13.10
- si:dkey-156m2.3
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- null
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa31246 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32799 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32801 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-nlrp3 | Tyrkalska et al., 2022 | |
MO1-nlrp3 | N/A | (2) |
1 - 2 of 2
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 34 | Alliance | Deafness, autosomal dominant 34, with or without inflammation | 617772 |
CINCA Syndrome | Alliance | CINCA syndrome | 607115 |
familial cold autoinflammatory syndrome 1 | Alliance | Familial cold inflammatory syndrome 1 | 120100 |
Muckle-Wells syndrome | Alliance | Muckle-Wells syndrome | 191900 |
Keratoendothelitis fugax hereditaria | 148200 |
1 - 5 of 5
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | Butyrophylin-like, SPRY domain | Concanavalin A-like lectin/glucanase domain superfamily | DAPIN domain | Death-like domain superfamily | Leucine-rich repeat | Leucine-rich repeat domain superfamily | NACHT-associated domain | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | NOD1/2, winged helix domain | NOD-like receptor (NLR) | P-loop containing nucleoside triphosphate hydrolase | SPRY-associated | SPRY domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M6YY09
|
1121 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
si:dkey-156m2.3-201
(1)
|
Ensembl | 6,595 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-114L13 | ZFIN Curated Data | |
Contained in | BAC | DKEY-156M2 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068222147 (1) | 6710 nt | ||
Genomic | GenBank:CU302202 (1) | 202236 nt | ||
Polypeptide | UniProtKB:A0A8M6YY09 (1) | 1121 aa |
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Tokumaru, T., Apolinario, M.E.C., Shimizu, N., Umeda, R., Honda, K., Shikano, K., Teranishi, H., Hikida, T., Hanada, T., Ohta, K., Li, Y., Murakami, K., Hanada, R. (2024) Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease. Scientific Reports. 14:78137813
- Tyrkalska, S.D., Pedoto, A., Martínez-López, A., Ros-Lucas, J.A., Mesa-Del-Castillo, P., Candel, S., Mulero, V. (2022) Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish. Developmental and comparative immunology. 138:104523
- Shan, C., Li, M., Liu, Z., Xu, R., Qiao, F., Du, Z.Y., Zhang, M.L. (2021) Pediococcus pentosaceus Enhances Host Resistance Against Pathogen by Increasing IL-1β Production: Understanding Probiotic Effectiveness and Administration Duration. Frontiers in immunology. 12:766401
- Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E. (2020) Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell. 55(2):133-149.e6
- Li, J.Y., Wang, Y.Y., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. The Journal of biological chemistry. 295(4):1120-1141
- Hu, Y.W., Yu, Z.L., Xue, N.N., Nie, P., Chang, M.X. (2014) Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Developmental and comparative immunology. 46(2):323-32
1 - 7 of 7
Show