Gene

samd8

ID

ZDB-GENE-070410-30

Name

sterile alpha motif domain containing 8

Symbol

samd8 Nomenclature History

Previous Names

zgc:162183

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within sphingolipid metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human SAMD8 (sterile alpha motif domain containing 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With samd8 Human Ortholog

No data available

Associated With samd8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR025749	Sphingomyelin synthase-like domain
Family	IPR045221	Sphingomyelin synthase-like
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily

1 - 4 of 4

Domain Details Per Protein

Protein	Additional Resources	Length	Sphingomyelin synthase-like	Sphingomyelin synthase-like domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily
UniProtKB:A0A8M6Z1F8	InterPro	386
UniProtKB:A4QNV5	InterPro	412

1 - 2 of 2

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 17

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	zgc:162183-201 (1) Ensembl	Ensembl		2,623 nt	Select Tool ZFIN BLAST
mRNA	zgc:162183-202 (1) Ensembl	Ensembl		4,624 nt	Select Tool ZFIN BLAST

1 - 2 of 2

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-288O11	CU928227	ZFIN Curated Data
Encodes	cDNA	MGC:162183	BC139536	ZFIN Curated Data

1 - 2 of 2

Show

Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001089470 (1)	2646 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX897736 (1)	141987 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A4QNV5 (1)	412 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	SAMD8	10	Ensembl:ENSG00000156671 Gene:142891 HGNC:26320 OMIM:611575	Phylogenetic tree (1) Amino acid sequence comparison (1)
Mouse	Samd8	14	Ensembl:ENSMUSG00000021770 Gene:67630 MGI:1914880	Phylogenetic tree (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

1 - 1 of 1

Show