Gene
mfsd4b
- ID
- ZDB-GENE-070410-26
- Name
- major facilitator superfamily domain containing 4B
- Symbol
- mfsd4b Nomenclature History
- Previous Names
-
- mfsd4b1 (1)
- zgc:162161
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable symporter activity. Predicted to act upstream of or within sodium ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator superfamily | MFS transporter superfamily |
|---|---|---|---|---|
| UniProtKB:A4QN56 | InterPro | 594 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mfsd4b-201
(1)
|
Ensembl | 2,517 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-78M17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162161 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089520 (1) | 2547 nt | ||
| Genomic | GenBank:CU570797 (1) | 105125 nt | ||
| Polypeptide | UniProtKB:A4QN56 (1) | 594 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | MFSD4B | 6 | Conserved genome location (synteny) (1) Phylogenetic tree (1) Amino acid sequence comparison (1) | |
| Mouse | Mfsd4b1 | 10 | Phylogenetic tree (1) Amino acid sequence comparison (1) Conserved genome location (synteny) (1) | |
| Mouse | Mfsd4b2 | 10 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) Phylogenetic tree (1) | |
| Mouse | Mfsd4b3-ps | 10 | Phylogenetic tree (1) Conserved genome location (synteny) (1) Amino acid sequence comparison (1) | |
| Mouse | Mfsd4b4 | 10 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) Phylogenetic tree (1) | |
| Mouse | Mfsd4b5 | 10 | Amino acid sequence comparison (1) Phylogenetic tree (1) Conserved genome location (synteny) (1) |
- Perland, E., Bagchi, S., Klaesson, A., Fredriksson, R. (2017) Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Open Biology. 7(9)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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