Gene
tnfrsf1b
- ID
- ZDB-GENE-070410-133
- Name
- tumor necrosis factor receptor superfamily, member 1B
- Symbol
- tnfrsf1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including peripheral nervous system axon ensheathment; positive regulation of hematopoietic progenitor cell differentiation; and regulation of non-canonical NF-kappaB signal transduction. Is active in plasma membrane. Is expressed in several structures, including head; head mesenchyme; hematopoietic system; osteoclast; and scale. Used to study psoriasis. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to several human genes including TNFRSF1B (TNF receptor superfamily member 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| psoriasis | nz50Tg + MO2-tnfrsf1b | standard conditions | Martínez-Navarro et al., 2020 |
| psoriasis | nc1Tg + MO2-tnfrsf1b | standard conditions | Martínez-Navarro et al., 2020 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor superfamily decoy receptor |
|---|---|---|---|
|
UniProtKB:A0A8M2B2L3
|
426 | ||
|
UniProtKB:F1RAS9
|
425 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf1b-201
(1)
|
Ensembl | 3,935 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-207B20 | ||
| Contained in | BAC | DKEYP-61B2 | ||
| Encodes | cDNA | MGC:163064 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089510 (1) | 3772 nt | ||
| Genomic | GenBank:CR848022 (1) | 141504 nt | ||
| Polypeptide | UniProtKB:A0A8M2B2L3 (1) | 426 aa |
- Dalle Carbonare, L., Minoia, A., Braggio, M., Bertacco, J., Piritore, F.C., Zouari, S., Vareschi, A., Elia, R., Vedovi, E., Scumà, C., Carlucci, M., Bhandary, L., Mottes, M., Romanelli, M.G., Valenti, M.T. (2023) Modulation of miR-146b Expression during Aging and the Impact of Physical Activity on Its Expression and Chondrogenic Progenitors. International Journal of Molecular Sciences. 24(17):
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Dalle Carbonare, L., Bertacco, J., Gaglio, S.C., Minoia, A., Cominacini, M., Cheri, S., Deiana, M., Marchetto, G., Bisognin, A., Gandini, A., Antoniazzi, F., Perduca, M., Mottes, M., Valenti, M.T. (2022) Fisetin: An Integrated Approach to Identify a Strategy Promoting Osteogenesis. Frontiers in pharmacology. 13:890693
- Kam, J.Y., Hortle, E., Krogman, E., Warner, S.E., Wright, K., Luo, K., Cheng, T., Manuneedhi Cholan, P., Kikuchi, K., Triccas, J.A., Britton, W.J., Johansen, M.D., Kremer, L., Oehlers, S.H. (2022) Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish. Nature communications. 13:952
- Molagoda, I.M.N., Athapaththu, A.M.G.K., Park, E.K., Choi, Y.H., Jeon, Y.J., Kim, G.Y. (2022) Fermented Oyster (Crassostrea gigas) Extract Cures and Prevents Prednisolone-Induced Bone Resorption by Activating Osteoblast Differentiation. Foods (Basel, Switzerland). 11(5):
- Wang, L., Ma, J., Wu, W., Fang, Y., Liu, F., Yang, Q., Hu, X., Gu, X., He, Z., Sun, D., Jin, L., Zhang, X. (2022) Effect of aerobic exercise as a treatment on type 2 diabetes mellitus with depression-like behavior zebrafish. Life sciences. 300:120578
- Carbonare, L.D., Bertacco, J., Marchetto, G., Cheri, S., Deiana, M., Minoia, A., Tiso, N., Mottes, M., Valenti, M.T. (2021) Methylsulfonylmethane enhances MSC chondrogenic commitment and promotes pre-osteoblasts formation. Stem Cell Research & Therapy. 12:326
- Han, Y., Shao, W., Zhong, D., Ma, C., Wei, X., Ahmed, A., Yu, T., Jing, W., Jing, L. (2021) Zebrafish mafbb Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients. Biomolecules. 11(3):
- Chen, H., Chen, K., Qiu, X., Xu, H., Mao, G., Zhao, T., Feng, W., Okeke, E.S., Wu, X., Yang, L. (2020) The reproductive toxicity and potential mechanisms of combined exposure to dibutyl phthalate and diisobutyl phthalate in male zebrafish (Danio rerio). Chemosphere. 258:127238
- Kobayashi-Sun, J., Yamamori, S., Kondo, M., Kuroda, J., Ikegame, M., Suzuki, N., Kitamura, K.I., Hattori, A., Yamaguchi, M., Kobayashi, I. (2020) Uptake of osteoblast-derived extracellular vesicles promotes the differentiation of osteoclasts in the zebrafish scale. Communications biology. 3:190
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