Gene
prf1.6
- ID
- ZDB-GENE-070410-126
- Name
- perforin 1.6
- Symbol
- prf1.6 Nomenclature History
- Previous Names
-
- prf8b (1)
- zgc:163021
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable wide pore channel activity. Predicted to be involved in T cell mediated cytotoxicity; defense response to virus; and immunological synapse formation. Predicted to act upstream of or within cytolysis. Predicted to be active in membrane. Is expressed in gill; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from Varela et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
Domain | IPR000008 | C2 domain |
Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
Family | IPR052784 | Perforin-1 pore-forming |
Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
Protein | Length | C2 domain | C2 domain superfamily | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Perforin-1 pore-forming |
---|---|---|---|---|---|---|
UniProtKB:A4QP80
|
516 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
prf1.6-201
(1)
|
Ensembl | 3,103 nt | ||
mRNA |
prf1.6-202
(1)
|
Ensembl | 907 nt |
Interactions and Pathways
No data available
Plasmids
No data available