ZFIN is now using GRCz12tu for Genomic Data
Gene
ctsbb
- ID
- ZDB-GENE-070323-1
- Name
- cathepsin Bb
- Symbol
- ctsbb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in diabetes mellitus and keratosis. Orthologous to human CTSB (cathepsin B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Keratolytic winter erythema | 148370 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR012599 | Peptidase C1A, propeptide |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal | Peptidase C1A, propeptide |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B7X2 | InterPro | 331 | |||||||
| UniProtKB:A4FUN3 | InterPro | 326 | |||||||
| UniProtKB:A0AB13ABU9 | InterPro | 326 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers