Gene
osr1
- ID
- ZDB-GENE-070321-1
- Name
- odd-skipped related transcription factor 1
- Symbol
- osr1 Nomenclature History
- Previous Names
-
- MGC:101674
- zgc:101674 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in angioblast cell differentiation; negative regulation of transcription by RNA polymerase II; and pronephric nephron development. Acts upstream of or within several processes, including kidney development; pectoral fin development; and regulation of nodal signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; germ ring; head; mesoderm; and vasculature. Orthologous to human OSR1 (odd-skipped related transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157130 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2H2-type Zinc-Finger Transcription Regulators | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:B2GQ48 | InterPro | 264 | |||
| UniProtKB:Q5XJQ7 | InterPro | 264 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:osr1-2A-BFP) |
| 1 | Perens et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-199E17 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7157130 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:101674 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191776 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006079 (1) | 1758 nt | ||
| Genomic | GenBank:BX470107 (2) | 252908 nt | ||
| Polypeptide | UniProtKB:B2GQ48 (1) | 264 aa |
- Yang, W., Liu, X., He, Z., Zhang, Y., Tan, X., Liu, C. (2024) odd skipped-related 2 as a novel mark for labeling the proximal convoluted tubule within the zebrafish kidney. Heliyon. 10:e27582e27582
- Drummond, B.E., Chambers, B.E., Wesselman, H.M., Gibson, S., Arceri, L., Ulrich, M.N., Gerlach, G.F., Kroeger, P.T., Leshchiner, I., Goessling, W., Wingert, R.A. (2022) osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 10(11):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Perens, E.A., Diaz, J.T., Quesnel, A., Askary, A., Crump, J.G., Yelon, D. (2021) osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation. Development (Cambridge, England). 148(15):
- Heger, P., Zheng, W., Rottmann, A., Panfilio, K.A., Wiehe, T. (2020) The genetic factors of bilaterian evolution. eLIFE. 9:
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Pinto, R.A., Almeida-Santos, J., Lourenço, R., Saúde, L. (2018) Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. BMC Developmental Biology. 18:14
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Chou, C.W., Hsu, H.C., You, M.S., Lin, J., Liu, Y.W. (2016) The endoderm indirectly influences morphogenetic movements of the zebrafish head kidney through the posterior cardinal vein and VegfC. Scientific Reports. 6:30677
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