Gene
gja12.2
- ID
- ZDB-GENE-070320-1
- Name
- gap junction protein alpha 12.2
- Symbol
- gja12.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Predicted to be located in plasma membrane. Predicted to be part of connexin complex.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37127 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Connexin | Connexin, N-terminal | Connexin, N-terminal domain superfamily | Gap junction protein, cysteine-rich domain |
|---|---|---|---|---|---|
|
UniProtKB:Q5TYN8
|
247 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cx28.1-201
(1)
|
Ensembl | 744 nt | ||
| mRNA |
cx28.1-202
(1)
|
Ensembl | 726 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261A18 | Iovine et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005170194 (1) | |||
| Genomic | GenBank:CR352322 (1) | 59134 nt | ||
| Polypeptide | UniProtKB:Q5TYN8 (1) | 247 aa |
No data available
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
- Mikalsen, S.O., Tausen, M., Í Kongsstovu, S. (2020) Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. BMC Genomics. 21:223
- Usui, Y., Aramaki, T., Kondo, S., Watanabe, M. (2019) The minimal gap-junction network among melanophores and xanthophores required for stripe-pattern formation in zebrafish. Development (Cambridge, England). 146(22):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cruciani, V., and Mikalsen, S.O. (2007) Evolutionary selection pressure and family relationships among connexin genes. Biological chemistry. 388(3):253-264
- Eastman, S.D., Chen, T.H., Falk, M.M., Mendelson, T.C., and Iovine, M.K. (2006) Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Genomics. 87(2):265-274
- Iovine, M.K., Higgins, E.P., Hindes, A., Coblitz, B., and Johnson, S.L. (2005) Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Developmental Biology. 278(1):208-219
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