Gene
utrn
- ID
- ZDB-GENE-070228-6
- Name
- utrophin
- Symbol
- utrn Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and zinc ion binding activity. Predicted to be located in several cellular components, including cytoskeleton; plasma membrane bounded cell projection; and postsynaptic membrane. Is expressed in lateral line system; muscle; notochord; pronephric duct; and somite border. Orthologous to human UTRN (utrophin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Böhm et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa918 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actinin-type actin-binding domain, conserved site | Calponin homology domain | CH domain superfamily | Dystrophin/utrophin | EF-hand domain pair | EF-hand domain, type 1 | EF-hand domain, type 2 | KCMF1 and Dystrophin | Spectrin/alpha-actinin | Spectrin repeat | WW domain | WW domain superfamily | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P595 | InterPro | 3523 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(4xUAS:utrn-GFP) |
|
| 1 | Chiang et al., 2017 | |
| Tg(actb2:mNeonGreen-tjp1b,actb1:utrn-mCherry) |
|
| 1 | Schwayer et al., 2019 | |
| Tg(EPV.Tp1-Mmu.Hbb:GFP-utrn) |
|
| 1 | So et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-284A16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-185M11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021469867 (1) | 11995 nt | ||
| Genomic | GenBank:CR376840 (2) | 128526 nt | ||
| Polypeptide | UniProtKB:A0A8M9P595 (1) | 3523 aa |
- Schwayer, C., Shamipour, S., Pranjic-Ferscha, K., Schauer, A., Balda, M., Tada, M., Matter, K., Heisenberg, C.P. (2019) Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Cell. 179:937-952.e18
- Chiang, I.K., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Hermkens, D., Lesieur, E., Liu, K., Ratnayaka, I., Corada, M., Bou-Gharios, G., Carroll, J., Dejana, E., Schulte-Merker, S., Hogan, B., Beltrame, M., De Val, S., Francois, M. (2017) SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development (Cambridge, England). 144(14):2629-2639
- So, J., Khaliq, M., Evason, K., Ninov, N., Martin, B.L., Stainier, D.Y.R., Shin, D. (2017) Wnt/β-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating Notch activity. Hepatology (Baltimore, Md.). 67(6):2352-2366
- See, K., Yadav, P., Giegerich, M., Cheong, P.S., Graf, M., Vyas, H., Lee, S.G., Mathavan, S., Fischer, U., Sendtner, M., and Winkler, C. (2014) SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Human molecular genetics. 23(7):1754-70
- Lai, D., Lan, C.C., Leong, I.U., and Love, D.R. (2012) Zebrafish dystrophin and utrophin genes: Dissecting transcriptional expression during embryonic development. International journal of molecular medicine. 29(3):338-348
- Böhm, S., Jin, H., Hughes, S.M., Roberts, R.G., and Hinits, Y. (2008) Dystrobrevin and dystrophin family gene expression in zebrafish. Gene expression patterns : GEP. 8(2):71-78
- Jin, H., Tan, S., Hermanowski, J., Bohem, S., Pacheco, S., McCaule, J.M., Greener, M.J., Hinits, Y., Hughes, S.M., Sharpe, P.T., Roberts, R.G., (2007) The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms. BMC Genomics. 8(1):19
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