ZFIN is now using GRCz12tu for Genomic Data
Gene
ercc6
- ID
- ZDB-GENE-070228-1
- Name
- excision repair cross-complementation group 6
- Symbol
- ercc6 Nomenclature History
- Previous Names
-
- CSB (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP-dependent chromatin remodeler activity. Acts upstream of or within DNA damage response and response to UV-C. Predicted to be active in nucleus. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Hernandez Herrera et al., 2026
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 5 | Alliance | {Macular degeneration, age-related, susceptibility to, 5} | 613761 |
| cerebrooculofacioskeletal syndrome 1 | Alliance | Cerebrooculofacioskeletal syndrome 1 | 214150 |
| Cockayne syndrome B | Alliance | Cockayne syndrome, type B | 133540 |
| De Sanctis-Cacchione syndrome | Alliance | ?De Sanctis-Cacchione syndrome | 278800 |
| lung cancer | Alliance | {Lung cancer, susceptibility to} | 211980 |
| primary ovarian insufficiency 11 | Alliance | Premature ovarian failure 11 | 616946 |
| UV-sensitive syndrome | Alliance | UV-sensitive syndrome 1 | 600630 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Cockayne syndrome | ercc6mn3001/mn3001 | standard conditions | Hernandez Herrera et al., 2026 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000330 | SNF2, N-terminal domain |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR049730 | SNF2/RAD5-like, C-terminal helicase domain |
| Domain | IPR058951 | Rad26/CSB-like, winged helix DNA-binding domain |
| Domain | IPR059240 | Excision Repair Cross Complementing 6, coiled-coil domain |
| Family | IPR050496 | SNF2/RAD54 Helicase and DNA Repair |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Excision Repair Cross Complementing 6, coiled-coil domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | Rad26/CSB-like, winged helix DNA-binding domain | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal domain | SNF2/RAD54 Helicase and DNA Repair | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z974 | InterPro | 1390 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers