Gene

rps6ka3b

ID

ZDB-GENE-070209-74

Name

ribosomal protein S6 kinase, polypeptide 3b

Symbol

rps6ka3b Nomenclature History

Previous Names

zgc:158386

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have ribosomal protein S6 kinase activity. Involved in ossification. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rps6ka3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Coffin-Lowry syndrome	Alliance	Coffin-Lowry syndrome	303600
non-syndromic X-linked intellectual disability 19	Alliance	Intellectual developmental disorder, X-linked 19	300844

Associated With rps6ka3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR017892	Protein kinase, C-terminal
Domain	IPR041906	Ribosomal S6 kinase, N-terminal catalytic domain
Family	IPR016239	Ribosomal protein S6 kinase II
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily