Gene

tbl1x

ID

ZDB-GENE-070209-131

Name

transducin beta like 1 X-linked

Symbol

tbl1x Nomenclature History

Previous Names

zgc:158242

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have transcription corepressor activity. Predicted to be involved in histone deacetylation and regulation of transcription by RNA polymerase II. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in Y-linked deafness 2 and congenital hypothyroidism. Orthologous to human TBL1X (transducin beta like 1 X-linked) and TBL1Y (transducin beta like 1 Y-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbl1x Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nongoitrous hypothyroidism 8	Alliance	Hypothyroidism, congenital, nongoitrous, 8	301033
Y-linked deafness 2	Alliance	?Deafness, Y-linked 2	400047

Associated With tbl1x Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR006594	LIS1 homology motif
Conserved_site	IPR019775	WD40 repeat, conserved site
Family	IPR045183	F-box-like/WD repeat-containing protein Ebi-like
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat