Gene
defbl2
- ID
- ZDB-GENE-070207-2
- Name
- defensin, beta-like 2
- Symbol
- defbl2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Is expressed in gut.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A1IVN0 | InterPro | 65 |
| UniProtKB:A0A8M1NBV9 | InterPro | 65 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
defbl2-201
(1)
|
Ensembl | 860 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-82A9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-11J5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-282G23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001081554 (1) | 862 nt | ||
| Genomic | GenBank:BX005026 (1) | 154034 nt | ||
| Polypeptide | UniProtKB:A0A8M1NBV9 (1) | 65 aa |
No data available
- Liao, X., Lan, Y., Wang, W., Zhang, J., Shao, R., Yin, Z., Gudmundsson, G.H., Bergman, P., Mai, K., Ai, Q., Wan, M. (2023) Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogens. Gut microbes. 15:21875752187575
- Novichkova, E., Nayak, S., Boussiba, S., Gopas, J., Zilberg, D., Khozin-Goldberg, I. (2023) Dietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut-Associated Gene Expression and Microbiome in the Zebrafish Model of IBD. Molecular Nutrition & Food Research. 67(6):e2200253
- Zheng, S.Y., Shao, X., Qi, Z., Yan, M., Tao, M.H., Wu, X.M., Zhang, L., Ma, J., Li, A., Chang, M.X. (2023) Zebrafish nos2a benefits bacterial proliferation via suppressing ROS and inducing NO production to impair the expressions of inflammatory cytokines and antibacterial genes. Fish & shellfish immunology. 142:109178
- Wasana, W.P., Senevirathne, A., Nikapitiya, C., Eom, T.Y., Lee, Y., Lee, J.S., Kang, D.H., Oh, C., De Zoysa, M. (2021) A Novel Pseudoalteromonas xiamenensis Marine Isolate as a Potential Probiotic: Anti-Inflammatory and Innate Immune Modulatory Effects against Thermal and Pathogenic Stresses. Marine drugs. 19(12):
- Nayak, S., Al Ashhab, A., Zilberg, D., Khozin-Goldberg, I. (2020) Dietary Supplementation with Omega-6 LC-PUFA-Rich Microalgae Regulates Mucosal Immune Response and Promotes Microbial Diversity in the Zebrafish Gut. Biology. 9(6):
- Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143
- Lazado, C.C., Nayak, S., Khozin-Goldberg, I., Zilberg, D. (2019) The gut mucosal barrier of zebrafish (Danio rerio) responds to the time-restricted delivery of Lobosphaera incisa-enriched diets. Fish & shellfish immunology. 89:368-377
- Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2019) Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. Developmental and comparative immunology. 101:103455
- Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274
- Cao, L., Wu, X.M., Hu, Y.W., Xue, N.N., Nie, P., Chang, M.X. (2018) The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. Developmental and comparative immunology. 84:153-163
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