Gene
nrxn1b
- ID
- ZDB-GENE-070206-3
- Name
- neurexin 1b
- Symbol
- nrxn1b Nomenclature History
- Previous Names
-
- nrxn1ba
- nrxn1bb
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to be involved in sprouting angiogenesis. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).
- Genome Resources
- Note
-
nrxn1b has two isoforms, alpha (DQ641426) and beta (DQ641427).
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kim et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pitt-Hopkins-like syndrome 2 | Alliance | Pitt-Hopkins-like syndrome 2 | 614325 |
| {Schizophrenia, susceptibility to, 17} | 614332 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR003585 | Neurexin/syndecan/glycophorin C |
| Domain | IPR027789 | Syndecan/Neurexin domain |
| Family | IPR050372 | Neurexin-related cell adhesion and synaptic protein |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin G domain | Neurexin-related cell adhesion and synaptic protein | Neurexin/syndecan/glycophorin C | Syndecan/Neurexin domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B4Y5 | InterPro | 1440 | ||||||
| UniProtKB:A1XQX3 | InterPro | 448 | ||||||
| UniProtKB:F1R7M4 | InterPro | 448 | ||||||
| UniProtKB:A0A8M3AYS8 | InterPro | 1431 | ||||||
| UniProtKB:A1XQX2 | InterPro | 1470 | ||||||
| UniProtKB:F8W597 | InterPro | 1475 | ||||||
| UniProtKB:A0A8M9PXV2 | InterPro | 217 | ||||||
| UniProtKB:A0A8M3B7R4 | InterPro | 1457 | ||||||
| UniProtKB:A0A8M3AYQ8 | InterPro | 1466 | ||||||
| UniProtKB:A0AB32T394 | InterPro | 439 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrxn1b-201
(1)
|
Ensembl | 7,191 nt | ||
| mRNA |
nrxn1b-202
(1)
|
Ensembl | 6,818 nt |
Interactions and Pathways
No data available
Plasmids
No data available