Gene

kcnma1a

ID

ZDB-GENE-070202-9

Name

potassium large conductance calcium-activated channel, subfamily M, alpha member 1a

Symbol

kcnma1a Nomenclature History

Previous Names

kcnma1
slo1a (1)
si:ch211-39f22.2

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have large conductance calcium-activated potassium channel activity. Involved in response to auditory stimulus. Predicted to localize to postsynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Is expressed in otic vesicle. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Rohmann et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnma1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
paroxysmal nonkinesigenic dyskinesia 3	Alliance	Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy	609446
		Cerebellar atrophy, developmental delay, and seizures	617643
		Liang-Wang syndrome	618729
		{Epilepsy, idiopathic generalized, susceptibility to, 16}	618596

Associated With kcnma1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003929	Calcium-activated potassium channel BK, alpha subunit
Domain	IPR005821	Ion transport domain
Domain	IPR048735	Ca2+-activated K+ channel Slowpoke-like, C-terminal domain
Family	IPR047871	Calcium-activated potassium channel slowpoke-like
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	Ca2+-activated K+ channel Slowpoke-like, C-terminal domain	Calcium-activated potassium channel BK, alpha subunit	Calcium-activated potassium channel slowpoke-like	Ion transport domain	NAD(P)-binding domain superfamily
UniProtKB:B7ZC96 InterPro PDB	1184
UniProtKB:F1QYL4 InterPro	1229
UniProtKB:A0A8M6Z3V4 InterPro	1151
UniProtKB:A0A8M3B7Y4 InterPro	1302
UniProtKB:A0A8M2B2Q5 InterPro	1233
UniProtKB:A0A8M3AYZ7 InterPro	1305
UniProtKB:A0A8M2B303 InterPro	1204
UniProtKB:A0A8M3B7Y9 InterPro	1252
UniProtKB:A0A8M9QNH1 InterPro	1244
UniProtKB:A0A8M6Z9M0 InterPro	1148
UniProtKB:A0A2R8QRZ7 InterPro	1229
UniProtKB:A0A8M2B3F4 InterPro	1208
UniProtKB:A0A8M9PY23 InterPro	1148
UniProtKB:A0A8M6Z2C3 InterPro	1152
UniProtKB:A0A8M3B560 InterPro	1301
UniProtKB:A0A8M3BEL0 InterPro	1263
UniProtKB:A0A8M6Z968 InterPro	1179
UniProtKB:A0A8M9QJS7 InterPro	1201
UniProtKB:A0A8M9PY17 InterPro	1208
UniProtKB:A0A8M6Z9L7 InterPro	1224
UniProtKB:A0A8M3AZ19 InterPro	1277
UniProtKB:A0A8M2B3K4 InterPro	1210
UniProtKB:A0A8M6Z1R0 InterPro	1180
UniProtKB:A0A8M9QNH5 InterPro	1204
UniProtKB:A0A8M3AZ02 InterPro	1252
UniProtKB:A0A8M2B2T1 InterPro	1232
UniProtKB:A0A8M9Q9V0 InterPro	1305
UniProtKB:A0A8M9QFI9 InterPro	672
UniProtKB:A0A8M3AZ25 InterPro	956
UniProtKB:A0A8M2B2Q8 InterPro	1206
UniProtKB:A0A8M3B563 InterPro	1213
UniProtKB:A0A8M2B2Z4 InterPro	1266
UniProtKB:A0A8M2B2S7 InterPro	1294
UniProtKB:A0A8M9QFI6 InterPro	1205
UniProtKB:A0A8M2B3E8 InterPro	1236
UniProtKB:A0A8M2B3J8 InterPro	1259

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kcnma1a-201 (1) Ensembl	Ensembl	4,328 nt	Select Tool ZFIN BLAST
mRNA	kcnma1a-205 (1) Ensembl	Ensembl	3,823 nt	Select Tool ZFIN BLAST
mRNA	kcnma1a-206 (1) Ensembl	Ensembl	3,690 nt	Select Tool ZFIN BLAST
ncRNA	kcnma1a-002 (1) Ensembl	Ensembl	849 nt	Select Tool ZFIN BLAST
ncRNA	kcnma1a-003 (1) Ensembl	Ensembl	725 nt	Select Tool ZFIN BLAST
ncRNA	kcnma1a-004 (1) Ensembl	Ensembl	857 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations