Gene
hs3st3b1b
- ID
- ZDB-GENE-070202-5
- Name
- heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b
- Symbol
- hs3st3b1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase activity. Predicted to be located in membrane. Is expressed in several structures, including fin; forebrain neural rod; nervous system; pectoral fin bud; and polster. Orthologous to several human genes including HS3ST3B1 (heparan sulfate-glucosamine 3-sulfotransferase 3B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010055Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la012215Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Heparan sulfate sulfotransferase | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|---|---|
| UniProtKB:A0MGY9 | InterPro | 396 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hs3st3b1b-201
(1)
|
Ensembl | 5,335 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-233B17 | ||
| Encodes | cDNA | MGC:194482 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194484 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080568 (1) | 1191 nt | ||
| Genomic | GenBank:CR847567 (1) | 126967 nt | ||
| Polypeptide | UniProtKB:A0MGY9 (1) | 396 aa |
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
- Pinto, R.A., Almeida-Santos, J., Lourenço, R., Saúde, L. (2018) Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. BMC Developmental Biology. 18:14
- Liu, C., Song, G., Mao, L., Long, Y., Li, Q., Cui, Z. (2015) Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish. PLoS One. 10:e0139612
- Choudhary, S., Burnham, L., Thompson, J.M., Shukla, D., and Tiwari, V. (2013) Role of Filopodia in HSV-1 Entry into Zebrafish 3-O-Sulfotransferase-3-Expressing Cells. The Open Virology Journal. 7:41-48
- Neugebauer, J.M., Cadwallader, A.B., Amack, J.D., Bisgrove, B.W., and Yost, H.J. (2013) Differential roles for 3-OSTs in the regulation of cilia length and motility. Development (Cambridge, England). 140(18):3892-3902
- Samson, S.C., Ferrer, T., Jou, C.J., Sachse, F.B., Shankaran, S.S., Shaw, R.M., Chi, N.C., Tristani-Firouzi, M., and Yost, H.J. (2013) 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biology. 11(12):e1001727
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Hubbard, S., Darmani, N.A., Thrush, G.R., Dey, D., Burnham, L., Thompson, J.M., Jones, K., and Tiwari, V. (2010) Zebrafish-Encoded 3-O-Sulfotransferase-3 Isoform Mediates Herpes Simplex Virus Type 1 Entry and Spread. Zebrafish. 7(2):181-187
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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