Gene
dtna
- ID
- ZDB-GENE-070117-2
- Name
- dystrobrevin, alpha
- Symbol
- dtna Nomenclature History
- Previous Names
-
- atnb
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to be involved in synaptic signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane and synapse. Is expressed in brain; notochord; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Böhm et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| left ventricular noncompaction | Alliance | Left ventricular noncompaction 1, with or without congenital heart defects | 604169 |
| Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2 | 620971 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000433 | Zinc finger, ZZ-type |
| Domain | IPR015153 | EF-hand domain, type 1 |
| Domain | IPR015154 | EF-hand domain, type 2 |
| Family | IPR017432 | Distrobrevin |
| Family | IPR050774 | KCMF1 and Dystrophin |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR043145 | Zinc finger, ZZ-type superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Distrobrevin | EF-hand domain pair | EF-hand domain, type 1 | EF-hand domain, type 2 | KCMF1 and Dystrophin | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PXM8 | InterPro | 697 | |||||||
| UniProtKB:A0A8M6Z4Q5 | InterPro | 696 | |||||||
| UniProtKB:A0A8M9P5Z6 | InterPro | 591 | |||||||
| UniProtKB:A0A8M2B9V6 | InterPro | 720 | |||||||
| UniProtKB:A0A8M9PU78 | InterPro | 696 | |||||||
| UniProtKB:A0A8M6YY42 | InterPro | 720 | |||||||
| UniProtKB:A0A8M6YW92 | InterPro | 722 | |||||||
| UniProtKB:A2CJ03 | InterPro | 714 | |||||||
| UniProtKB:A0A8M3ANS0 | InterPro | 728 | |||||||
| UniProtKB:A0A8M9PG52 | InterPro | 727 | |||||||
| UniProtKB:A0A8M9PLX9 | InterPro | 721 | |||||||
| UniProtKB:A0A8M6Z433 | InterPro | 727 | |||||||
| UniProtKB:A0AB32TIK0 | InterPro | 724 |
Interactions and Pathways
No data available
Plasmids
No data available