ZFIN is now using GRCz12tu for Genomic Data
Gene
drd4a
- ID
- ZDB-GENE-070112-996
- Name
- dopamine receptor D4a
- Symbol
- drd4a Nomenclature History
- Previous Names
-
- zgc:158147
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Acts upstream of or within spinal cord motor neuron cell fate specification and ventral spinal cord interneuron differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Reimer et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| attention deficit hyperactivity disorder | Alliance | {Attention deficit-hyperactivity disorder} | 143465 |
| Autonomic nervous system dysfunction |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dopamine D4 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8RMG6 | InterPro | 375 | ||||
| UniProtKB:A0A0R4IR92 | InterPro | 380 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers