Gene
drd4a
- ID
- ZDB-GENE-070112-996
- Name
- dopamine receptor D4a
- Symbol
- drd4a Nomenclature History
- Previous Names
-
- zgc:158147
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have adrenergic receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in spinal cord motor neuron cell fate specification and ventral spinal cord interneuron differentiation. Predicted to localize to integral component of plasma membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Is expressed in nervous system. Orthologous to human DRD4 (dopamine receptor D4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Reimer et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| attention deficit hyperactivity disorder | Alliance | {Attention deficit-hyperactivity disorder} | 143465 |
| Autonomic nervous system dysfunction |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dopamine D4 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:A0A2R8RMG6
|
375 | ||||
|
UniProtKB:A0A0R4IR92
|
380 |
Interactions and Pathways
No data available
Plasmids