Gene
ogg1
- ID
- ZDB-GENE-070112-932
- Name
- 8-oxoguanine DNA glycosylase
- Symbol
- ogg1 Nomenclature History
- Previous Names
-
- zgc:158858
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity. Acts upstream of or within several processes, including heart development; negative regulation of neuron apoptotic process; and regulation of neuron projection development. Predicted to be active in nucleus. Is expressed in several structures, including anterior lateral plate mesoderm; anterior presumptive neural plate; nervous system; pericardial region; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029498Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa34486 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3417 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ogg1 | Zhou et al., 2020 | |
| CRISPR2-ogg1 | Shin et al., 2021 | |
| MO1-ogg1 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonpapillary renal cell carcinoma | Alliance | Renal cell carcinoma, clear cell, somatic | 144700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003265 | HhH-GPD domain |
| Domain | IPR012904 | 8-oxoguanine DNA glycosylase, N-terminal |
| Family | IPR052054 | Oxidative DNA damage repair enzyme |
| Homologous_superfamily | IPR011257 | DNA glycosylase |
| Homologous_superfamily | IPR023170 | Helix-hairpin-helix, base-excision DNA repair, C-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | 8-oxoguanine DNA glycosylase, N-terminal | DNA glycosylase | Helix-hairpin-helix, base-excision DNA repair, C-terminal | HhH-GPD domain | Oxidative DNA damage repair enzyme |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7V0N6 | InterPro | 391 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196G2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-75A21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158858 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123308 (1) | 1322 nt | ||
| Genomic | GenBank:AL935148 (1) | 195396 nt | ||
| Polypeptide | UniProtKB:A0A8N7V0N6 (1) | 391 aa |
- Ravindra, J., Ug, Y., Pandyanda Nanjappa, D., Kalladka, K., Dhakal, R., Chakraborty, A., Chakraborty, G. (2023) Allicin extracted from Allium sativum shows potent anti-cancer and antioxidant properties in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 169:115854115854
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Lu, C., Luo, J., Liu, Y., Yang, X. (2020) The oxidative stress responses caused by phthalate acid esters increases mRNA abundance of base excision repair (BER) genes in vivo and in vitro. Ecotoxicology and environmental safety. 208:111525
- Shu, T., Zhai, G., Pradhan, A., Olsson, P.E., Yin, Z. (2020) Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation. General and comparative endocrinology. 295:113490
- Zhou, T., Zhang, J., Qin, B., Xu, H., Zhang, S., Guan, H. (2020) Long non‑coding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR‑4728‑5p/OGG1 axis. International journal of molecular medicine. 46:1838-1848
- Pei, D.S., Jia, P.P., Luo, J.J., Liu, W., Strauss, P.R. (2019) AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Cell Death & Disease. 10:348
- Zhao, G., Wang, Z., Xu, L., Xia, C.X., Liu, J.X. (2019) Silver nanoparticles induce abnormal touch responses by damaging neural circuits in zebrafish embryos. Chemosphere. 229:169-180
- Ho, T.N., Paul, G.V., Chen, Y.H., Hsu, T. (2018) Heat stress upregulates G-T mismatch binding activities in zebrafish (Danio rerio) embryos preexposed and nonexposed to a sublethal level of cadmium (Cd). Chemosphere. 218:179-188
- Jiang, J., Lv, L., Wu, S., An, X., Wang, F., Liu, X., Zhao, X. (2018) Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development. Chemosphere. 219:517-525
- Jiang, J., Shi, Y., Yu, R., Chen, L., Zhao, X. (2018) Biological response of zebrafish after short-term exposure to azoxystrobin. Chemosphere. 202:56-64
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