Gene
eif4g1a
- ID
- ZDB-GENE-070112-702
- Name
- eukaryotic translation initiation factor 4 gamma, 1a
- Symbol
- eif4g1a Nomenclature History
- Previous Names
-
- fb50a05
- wu:fb50a05
- wu:fc60b06
- zgc:158450 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Babu et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6009 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15272 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19718 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19719 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30815 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31270 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32876 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32877 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39804 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Parkinson disease 18} | 614251 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | Initiation factor eIF-4 gamma, MA3 | MIF4G-like, type 3 | Translation initiation factor eIF4G-like, eIF4E-binding domain | W2 domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A1L1W1 | InterPro | 1585 | |||||
| UniProtKB:A0A8M3B020 | InterPro | 1640 | |||||
| UniProtKB:A0AB32TYR8 | InterPro | 1592 | |||||
| UniProtKB:A0AB32U1U8 | InterPro | 1599 | |||||
| UniProtKB:A0AB32U379 | InterPro | 1600 | |||||
| UniProtKB:A0AB32U4V2 | InterPro | 1595 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif4g1a-201
(1)
|
Ensembl | 10,021 nt | ||
| mRNA |
eif4g1a-202
(1)
|
Ensembl | 6,454 nt | ||
| mRNA |
eif4g1a-203
(1)
|
Ensembl | 860 nt | ||
| mRNA |
eif4g1a-204
(1)
|
Ensembl | 9,910 nt | ||
| mRNA |
eif4g1a-205
(1)
|
Ensembl | 9,868 nt | ||
| mRNA |
eif4g1a-206
(1)
|
Ensembl | 9,898 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-211A15 | ZFIN Curated Data | |
| Contains | SNP | rs3727602 | ZFIN Curated Data | |
| Contains | SNP | rs3727603 | ZFIN Curated Data | |
| Contains | SNP | rs3727604 | ZFIN Curated Data | |
| Contains | SNP | rs3727605 | ZFIN Curated Data | |
| Contains | SNP | rs3727606 | ZFIN Curated Data | |
| Contains | SNP | rs3727607 | ZFIN Curated Data | |
| Contains | SNP | rs3727608 | ZFIN Curated Data | |
| Contains | SNP | rs3727609 | ZFIN Curated Data | |
| Contains | SNP | rs3727610 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080200 (1) | 5394 nt | ||
| Genomic | GenBank:CU462977 (1) | 102175 nt | ||
| Polypeptide | UniProtKB:A0A8M3B020 (1) | 1640 aa |
- Shu, T., Shu, Y., Gao, Y., Jin, X., He, J., Zhai, G., Yin, Z. (2018) Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. Frontiers in endocrinology. 9:683
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Babu, N.S., Murthy, C.L., Kakara, S., Sharma, R., Swamy, C.V., Idris, M.M. (2016) MPTP induced Parkinson's disease in zebrafish. Proteomics. 16(9):1407-20
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y.F., Yan, J.J., Tseng, Y.C., Chen, R.D., Hwang, P.P. (2015) Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. International journal of biological sciences. 11:1190-203
- Rösel, T.D., Hung, L.H., Medenbach, J., Donde, K., Starke, S., Benes, V., Rätsch, G., and Bindereif, A. (2011) RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. The EMBO journal. 30(10):1965-1976
- Tiefenbach, J., Moll, P.R., Nelson, M.R., Hu, C., Baev, L., Kislinger, T., and Krause, H.M. (2010) A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. PLoS One. 5(3):e9797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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