Gene

gnb5a

ID

ZDB-GENE-070112-342

Name

guanine nucleotide binding protein (G protein), beta 5a

Symbol

gnb5a Nomenclature History

Previous Names

zgc:158678

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Involved in heart contraction; optokinetic behavior; and swimming behavior. Predicted to localize to membrane. Orthologous to human GNB5 (G protein subunit beta 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Xu et al., 2012

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnb5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
intellectual developmental disorder with cardiac arrhythmia	Alliance	Lodder-Merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	617173
		Lodder-Merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	617182

Associated With gnb5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001632	G-protein, beta subunit
Family	IPR016346	Guanine nucleotide-binding protein, beta subunit
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat