Gene
git2b
- ID
- ZDB-GENE-070112-2192
- Name
- G protein-coupled receptor kinase interacting ArfGAP 2b
- Symbol
- git2b Nomenclature History
- Previous Names
-
- zgc:158416 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in brain development; regulation of signal transduction; and synaptic vesicle recycling. Predicted to act upstream of or within phosphorylation. Predicted to be active in synapse. Orthologous to human GIT2 (GIT ArfGAP 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yu et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001164 | Arf GTPase activating protein |
| Domain | IPR013724 | GIT, Spa2 homology (SHD) domain |
| Domain | IPR022018 | ARF GTPase-activating protein GIT1, C-terminal |
| Domain | IPR032352 | Arf GTPase-activating protein GIT1/2, coiled-coil domain |
| Family | IPR047161 | ARF GTPase-activating protein Git-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | ArfGAP domain superfamily | ARFGAP/RecO-like zinc finger | Arf GTPase activating protein | Arf GTPase-activating protein GIT1/2, coiled-coil domain | ARF GTPase-activating protein GIT1, C-terminal | ARF GTPase-activating protein Git-like | GIT, Spa2 homology (SHD) domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B2B2 | InterPro | 738 | |||||||||
| UniProtKB:A0A8M2B1P7 | InterPro | 706 | |||||||||
| UniProtKB:A0A8M2B236 | InterPro | 708 | |||||||||
| UniProtKB:A1L1V5 | InterPro | 736 | |||||||||
| UniProtKB:A0AB13A3I6 | InterPro | 706 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-249G19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158416 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080188 (1) | 5871 nt | ||
| Genomic | GenBank:AL953903 (1) | 180436 nt | ||
| Polypeptide | UniProtKB:A0A8M2B2B2 (1) | 738 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Yu, J.A., Foley, F.C., Amack, J.D., and Turner, C.E. (2011) The Cell Adhesion-associated Protein Git2 Regulates Morphogenetic Movements during Zebrafish Embryonic Development. Developmental Biology. 349(2):225-237
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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