Gene
ppp3ccb
- ID
- ZDB-GENE-070112-1102
- Name
- protein phosphatase 3, catalytic subunit, gamma isozyme, b
- Symbol
- ppp3ccb Nomenclature History
- Previous Names
-
- im:7163784
- zgc:158685
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to localize to calcineurin complex and cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in brain and head. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7163784 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
Domain | IPR006186 | Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
Domain | IPR041751 | PP2B, metallophosphatase domain |
Family | IPR043360 | PP2B |
Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
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Domain Details Per Protein
Protein | Length | Calcineurin-like phosphoesterase domain, ApaH type | Metallo-dependent phosphatase-like | PP2B | PP2B, metallophosphatase domain | Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
---|---|---|---|---|---|---|
UniProtKB:A0A8M2B273
|
502 | |||||
UniProtKB:A1L277
|
506 | |||||
UniProtKB:A0A8M2B1V9
|
511 | |||||
UniProtKB:F1QF86
|
506 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ppp3ccb-201
(1)
|
Ensembl | 2,233 nt | ||
ncRNA |
ppp3ccb-002
(1)
|
Ensembl | 517 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-159K22 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-66D7 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7163784 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:158685 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192715 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001080594 (1) | 2256 nt | ||
Genomic | GenBank:CR555296 (1) | 198271 nt | ||
Polypeptide | UniProtKB:A0A8M2B1V9 (1) | 511 aa |
- Zhao, J., Zong, W., Zhao, Y., Gou, D., Liang, S., Shen, J., Wu, Y., Zheng, X., Wu, R., Wang, X., Niu, F., Wang, A., Zhang, Y., Xiong, J.W., Chen, L., Liu, Y. (2019) In Vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development. eLIFE. 8:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Kujawski, S., Lin, W., Kitte, F., Börmel, M., Fuchs, S., Arulmozhivarman, G., Vogt, S., Theil, D., Zhang, Y., Antos, C.L. (2014) Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Developmental Cell. 28:573-87
- Hammond, D.R., and Udvadia, A.J. (2010) Cabin1 expression suggests roles in neuronal development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(9):2443-2451
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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