Gene
tbck
- ID
- ZDB-GENE-070112-1062
- Name
- TBC1 domain containing kinase
- Symbol
- tbck Nomenclature History
- Previous Names
-
- im:7138354
- wu:fc74a10
- zgc:158710
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within protein phosphorylation. Orthologous to human TBCK (TBC1 domain containing kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138354 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ma et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| infantile hypotonia with psychomotor retardation and characteristic facies-3 | Alliance | Hypotonia, infantile, with psychomotor retardation and characteristic facies 3 | 616900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000195 | Rab-GAP-TBC domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001763 | Rhodanese-like domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035969 | Rab-GAP-TBC domain superfamily |
| Homologous_superfamily | IPR036873 | Rhodanese-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Protein kinase domain | Protein kinase-like domain superfamily | Rab-GAP-TBC domain | Rab-GAP-TBC domain superfamily | Rhodanese-like domain | Rhodanese-like domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F1V3
|
893 |
Interactions and Pathways
No data available
Plasmids
No data available