Gene
sesn2
- ID
- ZDB-GENE-070108-1
- Name
- sestrin 2
- Symbol
- sesn2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of response to reactive oxygen species. Predicted to be located in cytoplasm and nucleus. Orthologous to human SESN2 (sestrin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Scheldeman et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AhpD-like | Sestrin |
|---|---|---|---|---|
| UniProtKB:A0F081 | InterPro | 444 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-181O15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162974 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079975 (1) | 1939 nt | ||
| Genomic | GenBank:CU104776 (1) | 106546 nt | ||
| Polypeptide | UniProtKB:A0F081 (1) | 444 aa |
No data available
- Tucker, S.K., Gosul, R., Swartz, M.E., Zhang, S., Eberhart, J.K. (2024) Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death. Development (Cambridge, England). 151(6):
- Zhao, T., Ye, S., Tang, Z., Guo, L., Ma, Z., Zhang, Y., Yang, C., Peng, J., Chen, J. (2021) Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish. Cell Death & Disease. 12:151
- Xu, H., Jiang, Y., Li, S., Xie, L., Tao, Y.X., Li, Y. (2020) Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Genes. 11(10):
- Ye, S., Zhao, T., Zhang, W., Tang, Z., Gao, C., Ma, Z., Xiong, J.W., Peng, J., Tan, W.Q., Chen, J. (2020) p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Cell Death & Disease. 11:568
- Kramer, A.C., Weber, J., Zhang, Y., Tolar, J., Gibbens, Y.Y., Shevik, M., Lund, T.C. (2017) TP53 Modulates Oxidative Stress in Gata1+ Erythroid Cells.. Stem Cell Reports. 8(2):360-372
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Zhou, X., Yue, G.G., Liu, M., Zuo, Z., Lee, J.K., Li, M., Tsui, S.K., Fung, K.P., Sun, H., Pu, J., Lau, C.B. (2016) Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Oncotarget. 7(50):82820-82835
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xu, T., Zhao, J., Yin, D., Zhao, Q., Dong, B. (2015) High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC Genomics. 16:23
- Peeters, H., Voz, M.L., Verschueren, K., De Cat, B., Pendeville, H., Thienpont, B., Schellens, A., Belmont, J.W., David, G., Van De Ven, W.J., Fryns, J.P., Gewillig, M., Huylebroeck, D., Peers, B., and Devriendt, K. (2006) Sesn1 is a Novel Gene for Left-Right Asymmetry and Mediating Nodal Signaling. Human molecular genetics. 15(22):3369-3377
1 - 10 of 11
Show