Gene

tnxba

ID

ZDB-GENE-070103-5

Name

tenascin XBa

Symbol

tnxba Nomenclature History

Previous Names

tnxb
si:dkey-8k3.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Orthologous to human TNXB (tenascin XB).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa12917	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa22795	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa39088	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa39089	Allele with one point mutation	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa42693	Allele with one point mutation	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)

1 - 5 of 5

Show

Sequence Targeting Reagents

No data available

Human Disease

Associated With tnxba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Ehlers-Danlos syndrome classic-like 1	Alliance	Ehlers-Danlos syndrome, classic-like, 1	606408
vesicoureteral reflux	Alliance	Vesicoureteral reflux 8	615963

1 - 2 of 2

Associated With tnxba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain	IPR003961	Fibronectin type III
Family	IPR050991	Extracellular Matrix Regulatory Proteins

1 - 5 of 9 Show all

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9P891	InterPro	2285
UniProtKB:A0A8M9PMY3	InterPro	851
UniProtKB:A0A8M9PDJ3	InterPro	2116

1 - 3 of 3

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 16

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tnxba-201 (1) Ensembl	Ensembl		5,383 nt	Select Tool ZFIN BLAST
mRNA	tnxba-202 (1) Ensembl	Ensembl		2,614 nt	Select Tool ZFIN BLAST

1 - 2 of 2

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-112P19	FP929006	ZFIN Curated Data
Contained in	BAC	CH211-257P13	CR848667	ZFIN Curated Data
Contained in	BAC	DKEY-8K3	CR848045
Contained in	BAC	DKEY-240N18	CR848809	ZFIN Curated Data

1 - 4 of 4

Show

Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_021466883 (1)	7648 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:FP929006 (2)	127251 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M9P891 (1)	2285 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	TNXB	6	Ensembl:ENSG00000236236 Gene:7148 HGNC:11976 OMIM:600985	Phylogenetic tree (1) Conserved genome location (synteny) (1) Nucleotide sequence comparison (1) Amino acid sequence comparison (1)
Mouse	Tnxb	17	Ensembl:ENSMUSG00000033327 Gene:81877 MGI:1932137	Amino acid sequence comparison (1) Phylogenetic tree (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

1 - 1 of 1

Show