Gene
hs6st3b
- ID
- ZDB-GENE-070103-3
- Name
- heparan sulfate 6-O-sulfotransferase 3b
- Symbol
- hs6st3b Nomenclature History
- Previous Names
-
- 6-ost-3 (1)
- hs6st3
- sb:eu962
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity; oligosaccharide binding activity; and sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Is expressed in several structures, including anterior neural keel; forerunner cell group; immature eye; nervous system; and tail bud. Orthologous to human HS6ST3 (heparan sulfate 6-O-sulfotransferase 3).
- Genome Resources
- Note
-
cloned by Cadwallader and Yost (2006)
- Comparative Information
-
- All Expression Data
- 12 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu962 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026883Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7632 | Allele with one point mutation | Unknown | Missense | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase |
|---|---|---|---|---|---|
| UniProtKB:B0S4Y4 | InterPro | 419 | |||
| UniProtKB:A0MGZ7 | InterPro PDB | 419 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hs6st3b-201
(1)
|
Ensembl | 1,260 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-87M5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-46K9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-177E22 | ZFIN Curated Data | |
| Encodes | EST | eu962 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:195363 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080194 (1) | 1433 nt | ||
| Genomic | GenBank:BX537139 (1) | 243063 nt | ||
| Polypeptide | UniProtKB:A0MGZ7 (1) | 419 aa |
- Horstick, E.J., Bayleyen, Y., Burgess, H.A. (2020) Molecular and cellular determinants of motor asymmetry in zebrafish. Nature communications. 11:1170
- Yu, T., Matsuda, M. (2020) Epb41l5 interacts with IQCB1 and regulates ciliary function in zebrafish embryos. Journal of Cell Science. 133(12):
- Xu, Y., Moon, A.F., Xu, S., Krahn, J.M., Liu, J., Pedersen, L.C. (2017) Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases. ACS Chemical Biology. 12:73-82
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Matsuda, M., Rand, K., Palardy, G., Shimizu, N., Ikeda, H., Nogare, D.D., Itoh, M., Chitnis, A.B. (2016) Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons. Development (Cambridge, England). 143(17):3085-96
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Cadwallader, A.B., and Yost, H.J. (2006) Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: II. The 6-O-sulfotransferase family. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(12):3432-3437
- Hsu, Y.C., Willoughby, J.J., Christensen, A.K., and Jensen, A.M. (2006) Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size. Development (Cambridge, England). 133(24):4849-4859
- Jensen, A.M., and Westerfield, M. (2004) Zebrafish Mosaic Eyes Is a Novel FERM Protein Required for Retinal Lamination and Retinal Pigmented Epithelial Tight Junction Formation. Current biology : CB. 14(8):711-717
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