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ZIRC
ZFIN ID: ZDB-GENE-061226-3
Gene Name: ryanodine receptor 2b (cardiac)
Gene Symbol: ryr2b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity; calcium-induced calcium release activity; and ryanodine-sensitive calcium-release channel activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to localize to several cellular components, including the Z disc; endoplasmic reticulum; and sarcolemma. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Is expressed in cardiac muscle; heart; heart primordium; and heart tube. Orthologous to human RYR2 (ryanodine receptor 2).
Genome Resources: Alliance (1),  Gene:568463 (1),  Ensembl(GRCz11):ENSDARG00000003706 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39158 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ryr2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arrhythmogenic right ventricular dysplasia 2 Alliance Arrhythmogenic right ventricular dysplasia 2 600996
    catecholaminergic polymorphic ventricular tachycardia 1 Alliance Ventricular tachycardia, catecholaminergic polymorphic, 1 604772
    DISEASE ASSOCIATED WITH ryr2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 20)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ryr2b-202 (1)    Ensembl 19846
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ryr2b No data available
    MARKER RELATIONSHIPS
    ryr2b Contained in: [BAC] CH211-125I17 (1) (order this), CH211-248A14 (1) (order this), DKEY-13B19 (1) (order this), DKEYP-90G2 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021467388 (1)
    Genomic GenBank:BX005070 242955 bp Blast at MegaBLAST
    Polypeptide UniProtKB:H1ZXA6 (1) 4916 aa
    Sequence Clusters UniGene:62024 (1)
    Sequence Information (all 31)
    ORTHOLOGY for ryr2b ( Chr: 17 )
    CITATIONS (30)