Gene
pdk3a
- ID
- ZDB-GENE-061220-3
- Name
- pyruvate dehydrogenase kinase, isozyme 3a
- Symbol
- pdk3a Nomenclature History
- Previous Names
-
- pdk3
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in regulation of acetyl-CoA biosynthetic process from pyruvate and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in brain and cardiac ventricle. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to human PDK3 (pyruvate dehydrogenase kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease X-linked dominant 6 | Alliance | ?Charcot-Marie-Tooth disease, X-linked dominant, 6 | 300905 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR005467 | Histidine kinase domain |
| Domain | IPR018955 | Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal |
| Family | IPR039028 | PDK/BCKDK protein kinase |
| Homologous_superfamily | IPR036784 | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily | Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal | Histidine kinase domain | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | PDK/BCKDK protein kinase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QMA3
|
405 | ||||||
|
UniProtKB:A0A8N7TD16
|
404 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-227M20 |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005162757 (1) | 6300 nt | ||
| Genomic | GenBank:CR759925 (1) | 38062 nt | ||
| Polypeptide | UniProtKB:A0A2R8QMA3 (1) | 405 aa |
- Miklas, J.W., Levy, S., Hofsteen, P., Mex, D.I., Clark, E., Muster, J., Robitaille, A.M., Sivaram, G., Abell, L., Goodson, J.M., Pranoto, I., Madan, A., Chin, M.T., Tian, R., Murry, C.E., Moon, R.T., Wang, Y., Ruohola-Baker, H. (2021) Amino acid primed mTOR activity is essential for heart regeneration. iScience. 25:103574
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
- Ghilardi, A., Diana, A., Prosperi, L., Del Giacco, L. (2020) Expression pattern of the small muscle protein, X-linked (smpx) gene during zebrafish embryonic and larval developmental stages. Gene expression patterns : GEP. 36:119110
- Lumley, A.I., Zhang, L., Ernens, I., Leszek, P., Devaux, Y. (2020) The long non-coding RNA landscape of cardiac regeneration in zebrafish. The Canadian journal of cardiology. 37(3):484-492
- Álvarez-Rodríguez, M., Pereiro, P., Reyes-López, F.E., Tort, L., Figueras, A., Novoa, B. (2018) Analysis of the Long-Lived Responses Induced by Immunostimulants and Their Effects on a Viral Infection in Zebrafish (Danio rerio).. Frontiers in immunology. 9:1575
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kuang, X., Liu, C., Fang, J., Ma, W., Zhang, J., Cui, S. (2016) The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. FEBS letters. 590(14):2076-85
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhuo, H.Q., Huang, L., Huang, H.Q., and Cai, Z. (2012) Effects of chronic tramadol exposure on the zebrafish brain: A proteomic study. Journal of proteomics. 75(11):3351-3364
1 - 10 of 11
Show