Gene
pdk3a
- ID
- ZDB-GENE-061220-3
- Name
- pyruvate dehydrogenase kinase, isozyme 3a
- Symbol
- pdk3a Nomenclature History
- Previous Names
-
- pdk3
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in glucose homeostasis and negative regulation of pyruvate dehydrogenase activity. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Is expressed in brain. Orthologous to human PDK3 (pyruvate dehydrogenase kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease X-linked dominant 6 | Alliance | ?Charcot-Marie-Tooth disease, X-linked dominant, 6 | 300905 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase |
| Domain | IPR005467 | Histidine kinase domain |
| Domain | IPR018955 | Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal |
| Family | IPR039028 | PDK/BCKDK protein kinase |
| Homologous_superfamily | IPR036784 | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily | Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal | Histidine kinase domain | Histidine kinase/HSP90-like ATPase | Histidine kinase/HSP90-like ATPase superfamily | PDK/BCKDK protein kinase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QMA3
|
405 | ||||||
|
UniProtKB:A0A8N7TD16
|
404 |
Interactions and Pathways
No data available
Plasmids
No data available