Gene
mgst3b
- ID
- ZDB-GENE-061215-48
- Name
- microsomal glutathione S-transferase 3b
- Symbol
- mgst3b Nomenclature History
- Previous Names
-
- mgstl (1)
- im:6905414
- wu:fa20h12
- zgc:158387
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Predicted to be involved in leukotriene metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Is expressed in brain; gill; liver; and pleuroperitoneal region. Orthologous to human MGST3 (microsomal glutathione S-transferase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6905414 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012420Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001129 | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein |
| Family | IPR050997 | Membrane-associated proteins in eicosanoid and glutathione metabolism |
| Homologous_superfamily | IPR023352 | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein | Membrane-associated proteins in eicosanoid and glutathione metabolism |
|---|---|---|---|---|
|
UniProtKB:A1A5Y1
|
140 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mgst3b-201
(1)
|
Ensembl | 1,158 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-9G4 | ZFIN Curated Data | |
| Encodes | EST | fa20h12 | ||
| Encodes | EST | IMAGE:6905414 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158387 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080034 (1) | 1078 nt | ||
| Genomic | GenBank:BX465191 (1) | 114405 nt | ||
| Polypeptide | UniProtKB:A1A5Y1 (1) | 140 aa |
- Bao, Z., Zhao, Y., Wu, A., Lou, Z., Lu, H., Yu, Q., Fu, Z., Jin, Y. (2020) Sub-chronic carbendazim exposure induces hepatic glycolipid metabolism disorder accompanied by gut microbiota dysbiosis in adult zebrafish (Daino rerio). The Science of the total environment. 739:140081
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Glisic, B., Mihaljevic, I., Popovic, M., Zaja, R., Loncar, J., Fent, K., Kovacevic, R., Smital, T. (2015) Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 158C:50-62
- Redelstein, R., Zielke, H., Spira, D., Feiler, U., Erdinger, L., Zimmer, H., Wiseman, S., Hecker, M., Giesy, J.P., Seiler, T.B., Hollert, H. (2015) Bioaccumulation and molecular effects of sediment-bound metals in zebrafish embryos. Environmental science and pollution research international. 22(21):16290-304
- Timme-Laragy, A.R., Goldstone, J.V., Imhoff, B.R., Stegeman, J.J., Hahn, M.E., and Hansen, J.M. (2013) Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Xu, H., Lam, S.H., Shen, Y., and Gong, Z. (2013) Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PLoS One. 8(7):e68737
- Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. (2011) Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One. 6(10):e26884
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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