Gene

atp13a2

ID

ZDB-GENE-061215-126

Name

ATPase cation transporting 13A2

Symbol

atp13a2 Nomenclature History

Previous Names

im:7147302
zgc:136762

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; ATPase activity; and metal ion binding activity. Involved in chordate embryonic development and locomotory behavior. Predicted to localize to integral component of membrane. Used to study Parkinson's disease and amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; and hereditary spastic paraplegia. Is expressed in brain. Orthologous to human ATP13A2 (ATPase cation transporting 13A2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147302 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp13a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 78	Alliance	Spastic paraplegia 78, autosomal recessive	617225
Kufor-Rakeb syndrome	Alliance	Kufor-Rakeb syndrome	606693

Associated With atp13a2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Parkinson's disease	AB + MO1-atp13a2	standard conditions	Lopes da Fonseca et al., 2013
Parkinson's disease	atp13a2^nii1/nii1	standard conditions	Nyuzuki et al., 2020
amyotrophic lateral sclerosis	WT + MO2-atp13a2 + MO3-atp13a2	standard conditions	Spataro et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004014	Cation-transporting P-type ATPase, N-terminal
Domain	IPR044492	P-type ATPase, haloacid dehalogenase domain
Domain	IPR047819	P5B-type ATPase, N-terminal
Family	IPR001757	P-type ATPase
Family	IPR006544	P-type ATPase, subfamily V
Family	IPR047821	P5B-type ATPase
Homologous_superfamily	IPR008250	P-type ATPase, A domain superfamily
Homologous_superfamily	IPR023214	HAD superfamily
Homologous_superfamily	IPR023298	P-type ATPase, transmembrane domain superfamily
Homologous_superfamily	IPR023299	P-type ATPase, cytoplasmic domain N
Homologous_superfamily	IPR036412	HAD-like superfamily
PTM	IPR018303	P-type ATPase, phosphorylation site