Gene
mapkapk3
- ID
- ZDB-GENE-061215-124
- Name
- MAPK activated protein kinase 3
- Symbol
- mapkapk3 Nomenclature History
- Previous Names
-
- zgc:158342
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; protein phosphorylation; and toll-like receptor signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| patterned macular dystrophy 3 | Alliance | ?Macular dystrophy, patterned, 3 | 617111 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050205 | Calcium-dependent Serine/Threonine Protein Kinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027442 | MAP kinase activated protein kinase, C-terminal |
Domain Details Per Protein
| Protein | Length | Calcium-dependent Serine/Threonine Protein Kinases | MAP kinase activated protein kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A1A5X1
|
408 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mapkapk3-201
(1)
|
Ensembl | 5,836 nt |
Interactions and Pathways
No data available
Plasmids
No data available