Gene
mapkapk3
- ID
- ZDB-GENE-061215-124
- Name
- MAPK activated protein kinase 3
- Symbol
- mapkapk3 Nomenclature History
- Previous Names
-
- zgc:158342
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; peptidyl-serine phosphorylation; and protein autophosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| patterned macular dystrophy 3 | Alliance | ?Macular dystrophy, patterned, 3 | 617111 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050205 | Calcium-dependent Serine/Threonine Protein Kinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027442 | MAP kinase activated protein kinase, C-terminal |
Domain Details Per Protein
| Protein | Length | Calcium-dependent Serine/Threonine Protein Kinases | MAP kinase activated protein kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A1A5X1
|
408 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mapkapk3-201
(1)
|
Ensembl | 5,836 nt |
Interactions and Pathways
No data available
Plasmids
No data available